Technicians deal with hazards on a daily basis, and so it would make sense that the earlier in the development process that hazards can be considered, the better. Certainly during scale-up, your project team will need to consider: Will I need to explore different material handling techniques because of the increased scaled-up volume of the API? If a successful Phase II or III project uses hazardous or flammable solvents, what are the operational risks associated with scaling the batch volume up to 100 or 1000 times?
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