Why don’t more OSD Research and Development Departments default to capsules instead of tablets for new products?
A tablet needs more ingredients than a capsule to keep the tablet structurally stable, reduce friability, and maintain the designated hardness parameters. The tablet also must include ingredients to help absorb the fluids of the gastrointestinal system so that it disintegrates easily to maximize the drug’s bioavailabilty. The dissolution and bioavailability of a capsule depend solely on the appropriate selection of the capsule materials. This simplifies the formulation inside.
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